Women’s Hair Loss After 40: Why It Happens and How CALECIM® Restores Follicle Health

Table of Contents

1. How CALECIM® Advanced Hair System Targets the Core Causes of Female Hair Loss After 40
2. Comparing Acellular Regeneration Calecim PTT-6 to Conventional FPHL Therapies
3. Clinical Protocol: Step-by-Step Guide to Using the CALECIM® Advanced Hair System
4. Understanding Women’s Hair Loss After 40: Hormones and Follicular Dysfunction

How CALECIM® Advanced Hair System Targets the Core Causes of Female Hair Loss After 40

The CALECIM® Advanced Hair System is an acellular regenerative topical treatment formulated to address hair thinning and loss by utilizing advanced cell-signaling technology, PTT-6®. This proprietary complex works at the root of follicular dysfunction by stimulating dermal papilla cell activity and neutralizing the inflammatory environment that often accelerates hair loss in women after age 40.  

CALECIM® achieves its effect by delivering highly concentrated paracrine signals directly to the scalp, reactivating dormant hair follicles and encouraging sustained, thicker hair growth.  

Key Mechanisms and Expected Benefits of PTT-6®:

• Advanced Cell Signaling: PTT-6® contains over 3,000 active proteins, growth factors, and exosomes that signal Dermal Papilla Cells (DPCs), which are necessary for hair initiation, to speed up follicle cell production.  
• Follicle Activation: Clinical research indicates PTT-6® causes a 24% increase in the growth of hair follicle cells, restoring a normal hair follicle cycle and prolonging the anagen phase.  
• Inflammation Modulation: The essential proteins within the system significantly mitigate scalp inflammation, showing a 30-fold reduction in inflammatory signals that typically trigger follicular cell death.  
• Observed Results Window: Patients in clinical settings reported visible results in as little as six weeks and showed mild to definitive improvements in density and thickness by the 12-week mark.  

Comparing Acellular Regeneration Calecim PTT-6® to Conventional FPHL Therapies

As Female Pattern Hair Loss (FPHL) is progressive and often requires long-term management, patients seek treatments that offer efficacy without major systemic side effects. While traditional therapies focus on vascular dilation or hormone blocking, PTT-6® introduces a distinct mechanism: targeted regenerative signaling that addresses inflammation and cell exhaustion.  

This distinction is crucial, as some clinical observations show that CALECIM® Advanced Hair System delivers excellent results even in patients who were unresponsive to minoxidil.  

Therapy	Primary Mechanism	Targeted Molecular Effect	Trade-offs and Mechanism Gaps
CALECIM® PTT-6®	Cell-Messaging, Regenerative Factors containing exosomes and growth factors	Promotes the proliferation of Dermal Papilla Cells (DPC) and reduces inflammatory signals by 30 times.	Must be administered with a derma stamper to ensure optimal delivery.
Topical Minoxidil	Vasodilator, Anagen Promoter	Improves blood flow, shortens the telogen phase, and partially activates the beta-catenin pathway.	Up to 40% of patients do not show significant improvements. It is primarily vascular-focused.
Oral Anti-Androgens	Systemic Hormone Inhibition	Slows androgen production and competitively inhibits DHT binding to receptors.	Risk of systemic side effects such as breast tenderness and weight gain. It requires physician supervision.

 

Clinical Protocol: Step-by-Step Guide to Using the CALECIM® Advanced Hair System

The CALECIM® Advanced Hair System is intended for in-clinic and at-home use, providing a structured regimen designed to optimize the delivery and function of the PTT-6® exosomal proteins.  

Step 1: Prepare the Scalp and Initiate Delivery

The formula’s large exosomal molecules require mechanical penetration enhancement for optimal absorption and to initiate the local healing response that synergizes with the regenerative factors.  

• What to do: Apply half an ampoule of the topical serum to the affected area.
• Key Instruction: Immediately follow application by using a derma stamper or dermaroller as recommended by your clinician.  

Step 2: Follow the Intensive Treatment Phase

This high-frequency phase is critical for overwhelming the negative signals in the aging follicle and driving cell regeneration.

• Frequency: Twice a week.  
• Duration: The intensive phase lasts 6 weeks.
• Mechanistic Rationale: Consistent twice-weekly application ensures sustained regenerative signaling to maximize the 24% increase in follicle cell activity and the 30-fold reduction in inflammatory cues.  

Step 3: Transition to the Maintenance Phase

After the initial 6 weeks, transitioning to a maintenance schedule helps sustain the proliferation and anti-inflammatory benefits achieved.  

• Frequency: Once a week.  
• Duration: Continue cycling between treatment and maintenance phases as guided by your professional.  
• Mechanistic Rationale: To maintain the enhanced nutrient delivery to the hair follicles and extend the anagen phase, continuous, albeit less frequent, application is necessary.  

Safety Note and Regulatory Guidance

The CALECIM® Advanced Hair System has consistently reported an excellent safety profile in case series, with no adverse events reported and high tolerability, making it suitable even for patients with sensitive skin.

Understanding Women’s Hair Loss After 40: Hormones and Follicular Dysfunction

Female Pattern Hair Loss (FPHL) is a chronic, progressive condition that becomes increasingly prevalent during the midlife transition, affecting more than half of women over 70 and 52.2% of healthy postmenopausal women in one study.

Why It Happens: The Hormonal Shift

The acceleration of hair thinning after age 40 is intrinsically linked to the hormonal environment of perimenopause and menopause.

1. Estrogen Decline: Estrogen normally plays a protective role by supporting hair growth (anagen) phase and maintaining follicle health. The decline of estrogen during menopause removes this stabilizing effect, leading to increased shedding and thinning.
2. Androgen Sensitivity: FPHL involves the miniaturization of hair follicles due to their heightened sensitivity to androgens like dihydrotestosterone (DHT). DHT binds to receptors in the hair bulb, triggering the pathological transformation of thick terminal hairs into thin vellus hairs.

The Molecular Failure: DKK-1 and WNT Signaling

The key molecular event driving FPHL is the breakdown of the signaling necessary to maintain the hair growth cycle.

• WNT Pathway Suppression: The WNT signaling cascade is critical for initiating and sustaining the anagen phase. However, in pattern hair loss, there is often a pathological upregulation of the antagonist protein.  
• Dickkopf WNT Signaling Pathway Inhibitor 1 (DKK-1) suppresses the WNT pathway and induces apoptosis (cell death) in Dermal Papilla cells.  
• Regenerative Countermeasure: The proprietary PTT-6® blend contains essential proteins designed to mitigate this suppression and deliver growth factors to the Dermal Papilla Cells, promoting the functional renewal needed in chronically aged follicles.  

Frequently Asked Questions (FAQs)

Q: Why is hair loss more emotionally damaging for women than men? 

A: Hair loss in women is strongly associated with profound psychological distress and reduced quality of life, leading to diminished self-confidence and self-esteem. Australian Journal of General Practice (AJGP) studies show 40% of affected women report marital problems, and 64% ascribe career difficulties to their alopecia.

Q: Can CALECIM® Advanced Hair System treat Minoxidil non-responders? 

A: Yes. Clinical observations have found that Calecim PTT-6® can be effective in patients who were unresponsive to conventional topical treatments, positioning it as an important alternative or adjunctive therapy for FPHL.  

Q: How does the exosome technology work? 

A: Exosomes are nano-sized messengers released by stem cells that contain complex instructions. Calecim harnesses these exosomes to communicate directly with hair follicle cells, stimulating growth and reducing localized inflammation.  

 Calecim Advance Hair System Quick-Specs

Feature	Detail
Primary Active Ingredient	PTT-6®, or the proprietary complex of proteins, growth factors, and exosomes
Treatment Frequency	Twice weekly application for 6 weeks
Maintenance Frequency	Once weekly application
Application Method	Must be used with a derma stamper or dermaroller
Key Benefits	Increases follicle activity by 24%, reduces inflammation by 30 times, and extends the anagen phase.
Results Window	Visible improvement in 6 to 12 weeks

Backed by Evidence

Study: Calecim PTT-6™, a novel topical hair serum with stem cell growth factors, significantly increases hair growth in patients with hair loss. A 12-week prospective, open-label Case series 

Author/Journal: Nikolaus Duschek, MD, PhD, et al.  

Key Metrics: This clinical case series demonstrated a 16% increase in hair shaft thickness and a 14% increase in the total number of hairs on the scalp after a 12-week application period.